Translational Immunology Laboratory

The Translational Immunology Lab works on Treg biology, the role of tissue in immune diseases and the genetics of primary immunodeficiencies

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The Primary Immunodeficiency Team focuses on understanding genetic defects in the human immune system. The team runs our immune phenotyping platform and gene discovery program. The gene discovery program has lead to the identification of multiple new primary immunodeficiencies and inflammatory diseases, including the discovery of Pyrin-associated autoinflammation and neutrophilic dermatosis, treatments for the newly identified CECR1 (ADA2)-deficiency, identifying the immune component of Olmsted syndrome and identifying IFIH1 mutations as a cause for juvenile lupus. We also develop new models of Primary Immunodeficiency, such as the first model of leaky SCID, and use mouse models to unravel the mechanism of disease, such as Treg-deficiency in HLH.

Key papers:

Masters et al, Science Translational Medicine

Carr et al, Nature Immunology 2016

Humblet-Baron et al, Journal of Allergy and Clinical Immunology 2016

Liston and Masters, Nature Reviews Immunology 2016

This project was set-up with funding from the European Research Council (ERC Start Grant) and has been supported in the past by the FWOJeffrey Modell Foundation and the University of Leuven. We accept donations to our charity to continue this research. 

If you are worried that your child may have a primary immune deficiency, look here to see the warning signs.