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Wednesday
Jun282017

Congratulations to Dr Emanuela Pasciuto

Dr Emanuela Pasciuto was successful in obtaining a highly competitive FWO post-doctoral fellowship to continue her neuroimmunology research in our laboratory.

She is a wonderful role model as a young mother who is a highly successful scientist. Congratulations Manu!

Friday
Jun232017

Good luck to our Masters class of 2017!

Tuesday
Jun132017

Work-life balance interview

The interview below was with Jorg Stange, the manager of the "equality4success" program at the Babraham Institute.

Why did you want to achieve a good work-life balance?

I don’t really think that I have achieved a good work-life balance. I work a lot more than I probably should, and I don’t have much time or hobbies or the like. I would love to have the time to learn a language and spend every weekend and evening work-free. On the other hand, I really like my work. Working 9 to 5 doesn’t sound appealing to me, and I don’t really make an attempt to firewall work and life.

The one place where I would say that I achieved a good work-life balance was in parenting duties. Many fathers automatically step into the part-time parenting role, happy for the mother to take most of the parenting duties. For me this is ideologically incompatible with having an equal relationship. I am a passionate feminist, so I actively seek not to replicate the typical mistakes of fatherhood. Equality in my relationship with my wife is a must, and I want to be a good example to my son.

But that doesn’t mean I have work-life balance – sometimes I have too much work AND too much parenting. When decisions on priority need to be made, I make sure that the most important facets of life come first, but the less important parts of both work and life sometimes get sacrificed.

Why do you think you have achieved a good WLB?

To the extent that I have, it is because I have amazing people in my life. My wife is an inspiring example of being successful at both work and at home, the people I work with are both amazing colleagues and wonderful friends. It is the support network for when things get tough that is most important. The other really important trick is being able to say no. Sometimes that means saying no to parts of work that are not critical (to keep up the parts that are most important), sometimes it means choosing to say no to parts of home life that are less important (but always preserving the important moments).

What actions did you take to maintain / improve WLB?

The big decisions need to always include both work and life. Where will you live on both the macro (which country/city) and micro (neighbourhood) needs to consider both aspects. Does the country have good healthcare and parental support? Will that city provide good career options for both people, or is someone going to become a trailing spouse? Does this neighbourhood provide an easy way to enjoy weekends, and a minimal commute during the week? If you make the big decisions deliberately friendly to both work and life, then the everyday decisions tend to fall in the right direction. For example, when I was working in the US, everyone around me worked late every evening and the lab was full every weekend. I had to make an effort to notice the time and leave before everyone else just to be home before 10pm. In Belgium, if I leave at 7pm I am often one of the last in the building: one work environment promotes long hours, the other discourages it.

What was the rationale behind these decisions?

I only see one good reason for life choices: being happy. My ideal work-life balance is going to be different from someone else’s. You would think that optimal happiness is something that we automatically drift towards, but actually (for me at least, and, I suspect, many others) it takes an awareness and an effort to arrange your life to be happy.

How did the working environment (attitudes of leaders and colleagues, policies in place, general culture, etc.) impact on your plans to achieve a better WLB?

Like many research institutes, my institute is a negative impact on work-life balance. Pressure is high, and I suspect it is physically impossible to achieve the required objectives within a normal working week. To do anything other than put work first constantly is to be an outlier.

On the other hand, Belgium as a country is very positive on my work-life balance. The culture is generally built around assumptions of normal working hours, and we picked key aspects of our life (where we life, where we work, where our son goes to school) to make healthy choices easier. Doesn’t mean that we always make them, but to a certain extent it counteracts the work pressure.

What support did you receive (from employer / national system / family)?        

The Belgian system is very good for young families – full day crèche from three months of age, great support from in-home nurse care during days when the child is sick, high quality schools everywhere so we can pick based on convenience and not feel guilty.

From my family, my wife and I took equal parenting very seriously, and so we both sacrificed either personal time or work success at various points. Our extended family are in Australia, so we were entirely reliant on each other and external support.

How did you benefit professionally from your solution to integrate life and work (e.g. increased motivation / creativity / focus)?

When I delegated work tasks to senior people in my laboratory, they stepped up to a much higher level than I expected, and things were soon being done better than I had been doing! When you give the right person responsibility you can be very pleasantly surprised, and they also get an opportunity to grow that they otherwise might not have.

How have your decisions for achieving WLB impacted on your career progression?

In the short term, it has probably been mildly negative. There are certainly meetings I should have attended that I didn’t, dinner that would have been good for my career that I skipped, grants I might have got that I didn’t write. On the other hand, I kept up all the really important career goals, so my career has been advancing better than I could have asked for. I certainly don't regret my choices for work-life-balance.

Saturday
Jun102017

Journal club: the origin of menopause

Menopause is, at face value, evolutionarily perplexing. Why select for the inability to breed, considering natural selection works only on the success of having offspring? Despite several claims, menopause is actually exceptionally rare - only humans and resident orcas (killer whales) have a systematic post-reproductive menopause state. It is rather hard to dissect the why in humans, but this study gives a good explanation of the demographic situation needed to evolve menopause. In short:

* Demographic situations where the offspring of mothers and daughters are in competition, plus where the offspring of daughters have an advantage (if the offspring of mothers have an advantage, breeding suppression in the young is observed)

* Social groups where the "grandmother" effect can aid the survival of the group (food sharing)

The implication is that these were key factors during human evolution, which would have molded our behaviour as well as our biology to maximise fitness.

Thursday
Jun082017

MutaMouse is open!

MutaMouse, our new genome engineering Core Facility, is now open! Come talk to us about making KO or KI mice for you!

Wednesday
Jun072017

Meet our Keynote speakers!

Saturday
Jun032017

Major upgrade to FACS Core

Our FACS Core is making major investments to equipment this year. We already have a new ImageStream, for image cytrometry, and a new Melody, for easy access sorting. Our latest arrival is the BD FACS Symphony, the pinnacle of flow cytometry, capable of 30-parameter single cell analysis!

Wednesday
May102017

Ways to succeed in science

Hidde Ploegh, Harvard/MIT, finished his lecture today with a message to the PhD students:
If you can buy it out of a catalog, you can assume that all the obvious experiments have been done. You will not make a major discovery or make an impact in the field until you develop new tools. You need to be willing to take a risk and invest in designing and building new strategies to look at old questions.
Very good advice, of course, coming from someone who has been incredibly successful in just this manner. There are many great immunologists who have made their mark in this way; Pippa Marrack and Gary Nolan spring to mind.
I would say that it is not the only way to be incredibly successful though. I tend to think of three basic types of high level success in science:
  • The builder. In the vein of Ploegh, Marrack or Nolan, they constantly build new technology or techniques to push back the boundaries of the possible
  • The bridger. There are many "builders" out there, working in different areas. And the tools created for one purpose always have great potential in other areas. The bridger is someone who keeps an open mind and an eye on many fields, looking for the opportunity to pull in a new approach or idea from another field into their own arena. Researchers like Diane Mathis, Sasha Rudensky and Jean-Laurant Casanova have been very successful in rewriting their field without inventing new technology. 
  • The thinker. Perhaps the rarest is the person who thinks of a simple elegant experiment that could actually have been done decades ago, but just wasn't. Not every advance relies on the brute force of new tech, some just need another way of looking at the problem. I see Gita Stockinger, Polly Matzinger, Ruslan Medzhitov and Chris Goodnow as successful in this approach. 
Of course, many of the best use aspects of each approach, and I am sure there are other models too.
Tuesday
May092017

MutaMouse Core Facility

Visit our website and found out what we can do for you!

Saturday
Apr292017

The Myth of Ethidium Bromide

Ethidium bromide is one of the most toxic chemicals found in a standard molecular biology lab, and should be used with extreme caution. Right? Actually, no. This interesting article pops the myth of ethidium bromide, which is actually safer than some of the "safe alternatives" on the market.